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Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52

Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52

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In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don’t Have To, and the host of the Lifespan Podcast, which launches January 5, 2022.

In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. We discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. We also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. We discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. We also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it.

#HubermanLab #DavidSinclair #Longevity

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00: 00: 00 Dr. David Sinclair, Harvard Medical School
00: 03: 30 ROKA, InsideTracker, Magic Spoon
00: 07: 45 “Aging as a Disease” vs. Longevity & Anti-Aging
00: 10: 23 What Causes Aging? The Epigenome
00: 15: 53 Cosmetic Aging
00: 17: 15 Development Never Stops, Horvath Clock
00: 20: 12 Puberty Rate as a Determinant of Aging Rate
00: 23: 00 Fasting, Hunger & Food Choices
00: 32: 44 Fasting Schedules, Long Fasts, (Macro)Autophagy
00: 34: 50 Caffeine, Electrolytes
00: 35: 56 Blood Glucose & the Sirtuins; mTOR
00: 37: 55 Amino Acids: Leucine, “Pulsing”
00: 44: 35 Metformin, Berberine
00: 50: 29 Resveratrol, Wine
00: 53: 20 What Breaks a Fast?
00: 56: 45 Resveratrol, NAD, NMN, NR; Dosage, Timing
01: 09: 10 Are Artificial Sweeteners Bad for Us?
01: 12: 04 Iron Load & Aging
01: 15: 05 Blood Work Analysis
01: 19: 37 C-Reactive Protein, Cholesterol: Serum & Dietary
01: 26: 02 Amino Acids, Plants, Antioxidants
01: 33: 45 Behaviors That Extend Lifespan, Testosterone, Estrogen
01: 40: 35 Neuroplasticity & Neural Repair
01: 46: 19 Ice Baths, Cold Showers, “Metabolic Winter”
01: 48: 07 Obesity & How It Accelerates Aging, GnRH
01: 52: 10 Methylation, Methylene Blue, Cigarettes
01: 56: 17 X-Rays
01: 59: 00 Public Science Education, Personal Health
02: 05: 40 The Sinclair Test You Can Take:
02: 08: 13 Zero-Cost Support & Resources, Sponsors, Patreon, Supplements, Instagram

The Huberman Lab Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.

Title Card Photo Credit: Mike Blabac –
Audio Engineering: Joel Hatstat at High Jump Media

De beste Nederlandse online gezondheidswinkel voor:

Veel mensen zoeken naar:

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25 gedachten over “Dr. David Sinclair: The Biology of Slowing & Reversing Aging | Huberman Lab Podcast #52

  1. The first episode of Dr. David Sinclair's new podcast launches Wednesday, January 5, 2022. You can subscribe now to that podcast, “Lifespan with Dr. David Sinclair”, on all podcast platforms ( ) and here on YouTube: Thank you for your interest in science!

  2. It is very strange to hear two doctors discuss how to get tests done. I'm like seriously? You got bodybuilders doing them. In India you can just book one on whim… and then I realise it is a plug for inside tracker. Facepalm. Well played.

  3. Does anybody know if one could get rid of eye floaters through autophagy? I've read somewhere that people with eye floaters have weak autophagy. I'm wondering could that be made better through prolonged fasting?

  4. First, I'm not a vegan, but I lean heavily on plants and I, too, come from a family of heart disease. I'm 63 and my father made it to 48 and my brother made it to 49. When I was 40 a lab technician noted significant signs of atherosclerosis while reviewing a scan of my lower back. A CT angiogram in my mid-50s showed no signs and that was after 3 years of strict plant-based eating in which I tracked my own lipids. Indeed, cholesterol studies are a mess, and this likely has something to do with the billions. of dollars in profits related to cholesterol-based foods. I can promise you that my serum cholesterol is dramatically influenced by cholesterol in my diet, and if a study doesn't start with a vegan or those that consume little to no cholesterol, then I would ignore their results. I also do not know the landscape of research in this area; however, I do know of at least one study on eggs that started with a group of Americans who were already consuming a lot of cholesterol. In that case, adding eggs–astonishingly ; ) –had no impact on serum cholesterol. “Amazing! Let us eat eggs!” it was funded by the egg industry or those with a vested interest in profits from the sale of eggs. The test is easy. Live without cholesterol for a month, get your lipids, then go back to a diet full of cholesterol and check it again. We don't need studies to prove this. And we don't need animal foods for amino acids: we need plants for the essential amino acids, which we can get from the animal that ate the animal that ate the plants, or we can get them from the plants directly. Heart disease is a choice for the vast majority of people, and I'm choosing to not have it.

  5. So, this guy is pushing for his product…..

  6. How can you make it easier for us viewers by always linking the supplements you use and or something ligit enough for us to look for. I have doubts on what and which and what brands are real and true for me as a consumer, not a scientist that may know the difference of what to get. Love your openess on educating the public, but of you can link the basic brands or ones your using, it would be appreciated!Whats the point in watching these videos if its not going to give us the sources your using? What it looks like is hours and hours of searching and reading and not knowing! For a mom that is very time consuming. Please link in supplements and what your using to cut back on our rat race of finding what your finding results with! Thanks Allah Bless You

  7. Andrew, fantastic job! You've placed all the right questions in order to complete the image of what Dr. David's explained, great work!

  8. Angina completely gone since taking reservatrol and NMN. Also doing intermittent fasting. Amazing info thank you. Life changing literally.

  9. 12:10. Reductionism is so silly, stop trying to put everything down into an equation. This is the kind of guy that tries to put spirituality and beauty into an equation and never ends up living because of it.

  10. I like the podcasts but the “uh huhs” are a bit difficult to listen to.

  11. I had a friend when I was younger who was bulimic and really skinny. Her cholesterol was through the roof! It was ridiculous that her doctor was telling her to eat less fatty foods .

  12. Would be interested in knowing if there is anything you take to retain hair colour?Thank you in advance, much appreciated.

  13. About ordering labs – as a functional medicine doc, I’d love to get all kinds of labs – and I used to just order them until my patients showed me bills they got from the lab for over $15,000. Insurance won’t cover much beyond the basics

  14. I love you guys for educating us amazing ,l follow you both ,from this podcast l have some idea how l ought to use my supplements, thank you so much ,l have forwarded this to my clients ,friends ,family .Marika Australia

  15. Nothing from the Government is free

  16. When David says that his testosterone levels were going down, I wonder if this is because of the supplements that he is taking? And is it bad that those levels are down, or should we get a testosterone booster supplement to compensate?

  17. When did Mayo clinic become reliable source?

  18. “I gave up sugar when I turned 40.” That guy looks 20 years old! I am amased!Another thing.. kudos to professor Huberman for saying Bulgarian yogurt not Greek yogurt. 🙂 I am a Bulgarian and I appreciate the accuracy. 🙂

  19. In Canada you can get bloodwork for free to an extent.

  20. Dietary cholesterol absolutely has an effect on serum cholesterol. Most people who follow a plant-based diet so a drop in cholesterol. My cholesterol dropped significantly after switching to a plant based diet.

  21. But what about the adrenals in regards to fasting? Or when you are already fasting without knowing because of stress or horrible work circumstances.

  22. I live Dr. Sinclair and his takes. I've followed all these crazy biohackers and they seem relentless and super strict but they are not PhDs, none are doctors! So I appreciate a non obsessive longevity perspective. I went to extremes with veganism for example and I became anemic. Years later I finally hear the first female doctor talk about fasting for females and it's absolutely different!!!!!

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