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Antioxidants NEW Approach: Sulforaphane, Astaxanthin & Protandim

Antioxidants NEW Approach: Sulforaphane, Astaxanthin & Protandim


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Direct antioxidants, unfortunately, didn’t live up to the hype with many trials showing that they don’t improve heart health or protect against cancer. Indirect antioxidants however, that activate an enzyme called NRF2, extend the lifespan of male mice.

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Here are the links to the research papers referenced in the video:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836174/

https://www.cochrane.org/CD007176/LIVER_antioxidant-supplements-for-prevention-of-mortality-in-healthy-participants-and-patients-with-various-diseases

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682992/

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#Antioxidants #Exercise #Health

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29 gedachten over “Antioxidants NEW Approach: Sulforaphane, Astaxanthin & Protandim

  1. BTW, a dedicated video looking at Moringa is coming 🙂

  2. Brad, thank you for this video. My problem is that I want to take Sfn , But I only rest one day per week. I am 48 years old. I tried to look more carefully into your assertion that it would be bad to take a sfn on workout days. I am also considering the fact that it is thought that duration of the impact of sfn is likely as much as a few days. Thus, It will be very difficult for me to maintain my exercise regimen and not have an impact of the SFN on my training. While I completely understand your argument, and I do not think to the contrary, from what I have read it is likely that performance is enhanced from taking sfn Because the body is able to absorb more ROS during exercise. Thus, you may reach a higher level of performance or intensity, and produce the same amount of ROS as you would have without SFN. In such a case there would be no blunting. Of course, there can be other affects than just ros saturation on performance. If the limiting variable to performance is not ROS, And is instead something else, then your assumption that SFn May Blunt the positive benefits of exercise seems more valid. But I think it is fair to say that at least in some kind of exercise, more in aerobic training I think, that ROS is at least one of the limiting factors to performance. If ROS is also important in resistance training, then I can imagine that it might be beneficial for hypertrophy to take sfn Since it may help you to have a more intense workout where you break down more muscle fibers that can subsequently be grown back stronger. Right now my plan is to concentrate my SFn dosing Around my rest day. At least I will have some days of the week where my training is in no way impacted by it. But I am not sure I’m doing the right thing, and honestly I’m somewhat concerned that for someone training as much as me That it might be best simply to not take sfn; This is not my current assumption but I am concerned that it could be the case. I would very much appreciate any help related to timing SFn around training Of different types, meaning resistance versus cardio, And the scientific rationale for whatever you recommend.Thanks.

  3. Dr. Brad, what amount of movement do you have during “Rest Days? I believe that Dr. Greger reports that 90 min. of moderate exercise per day is ideal for most. I would love to see videos of high, moderate, mild exercises and what might be a good program for people by sex, chronical age, and some version of biological age. At my age, 72, and Inside Tracker inner age of 62, a rest day of no exercise results in, well, guilt!, but less lithe, energetic feelings. So I add an hour's walk, an easy swim, and mild yardwork, for example. How about video clips of what moderate elliptical looks like, or HIIT videos? Thank you for your thrilling and informative videos, Dr. Stanfield. I so wish you lived near enough to be my husband's and my doctor! We now live in Florida, and we have found a few plant-based docs, 1-3 hours away. So we now have found an acceptable regular doc in our town in case of emergencies and shall choose a plant-based doc for telemed sessions when we have questions and seek advice. But so far, the two we have located are very negative about taking supplements. Please let us know if you are licensed to see or do consultations to suggest and look at test results and advise people in Florida! Yes, we realize you are not plant-based and wonder why. Just a clear set of points why you have chosen that pattern and if you have seen say, 10 hours of the research Dr. Greger reports on.

  4. I exercise every day, what to do?

  5. You’re channel is absolutely fantastic. I’ve learned so much from you. Please keep at this, I’m shocked your channel hasn’t absolutely blown up yet.

  6. Dr Brad have you ever looked into meditation ect and the effectiveness on maintaining a young mind and body. Reduced inflammation ect.Not only vitamins provide life/health span benifits

  7. I inadvertently did a pretty massive n=1 study of this idea. I ingested massive amounts of nf2 activators. I was eating over a cup of raw garlic, ginger,etc each day for over a month. This was all in a desperate attempt to recover from 2 years of very intense chemo for leukemia. I don’t know if anyone on the planet has consumed as much of the stuff that I did. In the end, I came close to dying, and I suffered some pretty significant blood problems which are only down getting back to normal. This was 6 years ago. But, my question is this… how would you suggest determining if it worked (helped recover from the chemo, slow of reverse aging)? I was a pretty competitive athlete. My thought is that if I can be faster at 50 then I was at 25, then that would imply that it worked. I think that if a blood test suggested I had turned back the clock, I’d be happy, but I wouldn’t fully trust the blood test. But, if I could set some lifetime personal bests, then I think that would offer pretty good proof that it worked. Thoughts?

  8. Why not just get your Sulforaphane from garlic, onions, kale, cabbage etc?

  9. Would an anti-oxidative stress manifest in higher CRP, like oxidative stress is likely to do?

  10. You are giving us the research work in progress. Give us some conclusive evidence.

  11. This study performed on 2020 suggest that here is actually benefits take sulforaphane on extreme exercis.. Look:Regular exercise is beneficial to maintain a healthy lifestyle, but the beneficial effects are lost in the case of acute exhaustive exercise; this causes significant inflammation, oxidative stress along with organ damage. Recently, sulforaphane (SFN), an indirect antioxidant, has drawn special attention for its potential protective effect against inflammation and oxidative stress. However, no studies have been performed regarding acute exhaustive exercise-induced organ damage in association with SFN administration. Therefore, the aim of this study was to investigate the effects of SFN on acute exhaustive exercise-induced organ damage and the mechanisms involved. To perform the study, we divided mice into four groups: Control, SFN, exercise, and SFN plus exercise. The SFN group was administered orally (50 mg/kg body wt) 2 h before the running test. We measured plasma levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH), and acute exhaustive exercise significantly increased these biomarkers. In addition, the mRNA expression of pro-inflammatory cytokines, IL-6, IL-1β, and TNF-α, were significantly increased in the liver of exercise group. However, the SFN plus exercise group showed a significant reduction in the expression of cytokines and blood biomarkers of tissue damage or cell death. Furthermore, we measured mRNA expression of Nrf2, heme oxygenase (HO)-1, and antioxidant defense enzymes expression, i.e., superoxide dismutase (SOD1), catalase (CAT), and glutathione peroxidase (GPx1) in the liver. The expression of all these biomarkers was significantly upregulated in the SFN plus exercise group. Collectively, SFN may protect the liver from exhaustive exercise-induced inflammation via inducing antioxidant defense response through the activation of Nrf2/HO-1 signal transduction pathway.

  12. Great information, and Yes, please review human clinical trials that activate Nf2.

  13. Hi Dr branfield. Can you look into the studies that shows metformin and exercise counteract each other. The studies i read showed counteraction in insulin – but those studies done was exercising of metformin with no food so could that maybe show that effect bc of no food.

  14. Shouldn't DIM be used instead of Sulforaphane? Sulforaphane creates unwanted metabolites.

  15. The paper discussed reported on mice. Human subjects may be different.

  16. What about DIM? Should one add DIM to the supplement list?

  17. Dr. BRAD HAVE YOU A VIDEO about fermented foods and lower inflammation. 2021 study

  18. Is eating row broccoli instead of supplements not adequate for taking sulforaphane ?

  19. For me, if I took only on rest days, that would only be one day out of the week. Doesn't seem like that would be of much benefit.

  20. I have a totally occluded mid right artery and rely on isosorbide mononitrate, double dose for angina. I started taking astaxanthin two weeks ago and for the past week I have not had an angina attack andhae not takem iso-m at all, not event had to use the oral spray.

  21. In Jeff Fahey's video with Dr Patrick, he said that NFR2 activates enzymes that take 24 hours to reach maximal effect. The enzymes must have a half life and will remain active for a period of time. I would think that this makes alternating sulphorapone and exercise days a useless. exerxise. What is your opinion on this? PS: There is a stable sulforaphane product made from broccoli seeds available in the US called BROQ It has been available in France for a number of years under a different name.,

  22. Is there any data that can help us determine a time window around exercise, in which we'd want to avoid blunting oxidative stress? If you work out in the morning or early afternoon, would supplementing Sulforaphane, Astaxanthin & Protandim in the evening be OK?

  23. If antioxidants are generally not a solution to aging, does it mean that the immense amount of advice we've heard about eating a lot of highly pigmented fruits and vegetables is wrong?

  24. Bro, your skin is great

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